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Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€374,40 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€174,20 Add to cart -
OTK4/FKBP1B/FKBP12.6 [H8]
Description Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBPtype PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, equine, Dog (Canine), Bovine, Pig 
1 ml more info 14 days
€361,40 Add to cart -
PAX5 [A11]
Description PAX5 is a B-cell lineage specific activator protein (BSAP) that is essential for maintaining the identity and function of mature B cells during late B lymphopoiesis. It also plays a role in neural development and spermatogenesis. PAX5 is expressed in pro-, pre-, and mature B cells, and it is expressed in the vast majority of B-cell malignancies. Anti-PAX5 is a specific marker for the B cell lineage. PAX5 is thus useful for a panel of antibodies for the identification of cellular origin of undifferentiated tumors. The expression of PAX5 in endocrine tumors has been shown to be high in Merkel cell carcinoma and small cell carcinoma, but not carcinoid tumor. PAX5 is also a marker for nueronendocrine carcinomas. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
PAX5 [A11]
Description PAX5 is a B-cell lineage specific activator protein (BSAP) that is essential for maintaining the identity and function of mature B cells during late B lymphopoiesis. It also plays a role in neural development and spermatogenesis. PAX5 is expressed in pro-, pre-, and mature B cells, and it is expressed in the vast majority of B-cell malignancies. Anti-PAX5 is a specific marker for the B cell lineage. PAX5 is thus useful for a panel of antibodies for the identification of cellular origin of undifferentiated tumors. The expression of PAX5 in endocrine tumors has been shown to be high in Merkel cell carcinoma and small cell carcinoma, but not carcinoid tumor. PAX5 is also a marker for nueronendocrine carcinomas. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€401,70 Add to cart -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
Perforin [E-5]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Perforin [E-5]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Pgp9.5/UCHL1 [31A3]
Description Protein gene product 9.5 (PGP 9.5), also known as ubiquitin carboxyl-terminal hydrolase-1 (UCH-L1), is a 27-kDa protein originally isolated from whole brain extracts (1). Although PGP9.5 expression in normal tissues was originally felt to be strictly confined to neurons and neuroendocrine cells, it has been subsequently documented in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. LK PGP 9.5 has been demonstrated immunostaining of a plethora of different mesenchymal neoplasms with this antibody. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine,Pig (Porcine)
1 ml more info 14 days
€361,40 Add to cart
