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KRT20 antibody
Description Mouse Monoclonal KRT20 antibody (Shipping Cost: €205.00) Host Mouse Application ELISA,Western Blot (WB),Immunocytochemistry (ICC),Immunofluorescence (IF),Flow cytometry (FC) Concentration 1 mg/ml -
14.3.3 epsilon antibody
Host Mouse Application ELISA,Western Blot (WB),Flow cytometry (FC),Immunocytochemistry (ICC),Immunofluorescence (IF) Concentration 1 mg/ml Specificity Human -
Bone Sialoprotein
Host Chicken Application Immunohistochemistry on paraffin sections (IHC-P),ELISA,Western Blot (WB),Radioimmunoassay (RIA),Flow cytometry (FC),Immunocytochemistry (ICC) Reactivity Human Alternative names Human Bone Sialoprotein (native protein) -
Bone Sialoprotein
Host Chicken Application Immunohistochemistry on paraffin sections (IHC-P),ELISA,Western Blot (WB),Radioimmunoassay (RIA),Flow cytometry (FC),Immunocytochemistry (ICC) Reactivity Human Alternative names Human Bone Sialoprotein (native protein) -
Blood Group Antigen Lewis A [7LE]
Description Recognizes a carbohydrate determinant of Gal 1-3(Fuc 1-4) GlcNAc which is blood group antigen Lewis A. It is present primarily on epithelial cells such as colon and kidneys. In the tumors and dedifferentiated tissues, decrease of Lewis A antigen was observed. Lewis A (type 1 chain) is expressed in colonic epithelial cells and may be useful for detection of gastrointestinal tumors, pancreatic cancer, and colorectal tumors. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse -
C5b9/TCC/MAC [aE11]
Description The complement component proteins: C2, C3, C4 and C5 are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)-F Reactivity Human, Horse,Pig (Porcine), Monkey, Baboon -
CD130/gp130/IL-6RB [AN-H2]
Description The activation of the IL-6 protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL-6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the IL-6 receptor (IL-6R) and directly activate this protein. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity. The protein encoded by this gene is a signal transducer shared by Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CD130/gp130/IL-6RB [AN-H2]
Description The activation of the IL-6 protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL-6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the IL-6 receptor (IL-6R) and directly activate this protein. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity. The protein encoded by this gene is a signal transducer shared by Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human -
CD95/FAS/TNFRSF9 [MD86]
Description The CD95 (Fas) protein is a cell surface receptor belonging to the tumor necrosis factor (TNF) family that transduces death signaling on engagement by multimeric Fas ligand (CD95L), of which there are eight in its membrane –bound form or in its soluble form resulting from cleavage by a putative metalloproteinase. CD95 is a widely expressed protein. CD95-mediated apoptosis is an essential mechanism for the maintenance of normal tissue homeostasis, and disruption of this death pathway has been associated with a wide range of human diseases, including autoimmune diseases, lymphoproliferative disorders and malignancies. The Fas death system also plays important roles in various apoptosis conditions such as those evoked by irradiation, chemotherapeutic agents and viral infections. The expression of CD95 serves as a prognostic marker in predicting the outcome of disease progression and treatment in many types of tumors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human